Association between serum level of pentraxin-3 and interleukin-40 with HCC disease in Egypt

Said, Noha Mohamed; Yassin, Fathy; Esh, Asmma M.; Saeed, Eman

doi:10.21608/blj.2020.146586

Association between serum level of pentraxin-3 and interleukin-40 with HCC disease in Egypt

Document Type : Original Article

Authors

¹ Biochemistry Division, Chemistry Department, Faculty of science, Zagazig University, Zagazig, Egypt

² Chemistry Department, Faculty of science, Zagazig University, Zagazig, Egypt

³ Clinical Pathology Department, Faculty of Medicine ,Zagazig university , Zagazig ,Egypt.

10.21608/blj.2020.146586

Abstract

Background Hepatocellular carcinoma (HCC) is a global public health problem that lacks efficient methods for early diagnosis. The inflammation of the hepatocytes due to the cirrhosis caused by HCC can be reflected by the disturbance in the level of some proteins secreted by the inflammatory immune cells. We aimed to study pentraxin-3 (PTX3) and interleukin-40 (IL-40) blood levels in patients with HCC Material and method This study included 46 of HCC patients and 24 of control with no history of malignancy. All the volunteers are subjected to complete clinical examination and routine laboratory analysis including CBC, coagulation profile tests, liver and kidney function tests. Serum levels of AFP, interleukin-40, and pentraxin-3 were measured by the ELISA technique Results Both PTX3 and IL-40 blood levels were significantly higher in HCC patients compared to healthy controls (P < 0.05). In addition both of them high AUC under ROC curve with significant value (AUC= 0.97, P <0.001; AUC=0.745, P= 0.016) for PTX3 and IL-40 respectively. Almost no studies have discussed the role of IL-40, which is new characterized cytokine, with HCC disease. Conclusions: This study suggested thatpatients with HCC showed increased presence of PTX3 and IL-40 serum level which may suggest a potential relationship of both of them with HCC. Although the role of IL-40 in HCC pathogenesis and development is still unclear but several studies have revealed that HCC progression is solely dependent on the extent of liver inflammation, hence, the balance between pro-inflammatory and anti-inflammatory cytokines is the key ingredient for controlling the disease progression.

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