Background: Thiazole derivatives are a category of hetero
cyclic compounds that large spectrum of biological
activities.Aim: This study aim to study the anti cancer
effect of thiazole derivatives invitro and invivo.Methods:
Synthesis of thiazole derivatives were examined invitro
and invivo .Results: Invitro , IC50 of Compound1 on
different human lines colon cancer, breast cancer and liver
cancer were found 4.7 ug/ml, 4.8 ug/ml and 11 ug /ml
respectively. While IC50 value for Compound 2 were
found 9.5 ug/ml , 9.6 ug/ml and 18 ug /ml respectively.
Invivo , these compounds were safe up to 500
mg/Kg.Although the most effective doses was 15 mg/kg
for Compound1 and Compound2. Thiazole derivatives
showed a significant reduction in the volume and count of
Ehrlich ascites carcinoma and improve hematological
parameters ,liver and kidney functions.Conclusion:
Thiazole derivatives have apotent antitumor activity .
Keshta, A., Moustafa, M., Ashour, H., & Zahran, F. (2022). Anti Cancer effect of two new synthized hetero cyclic compounds.. Biochemistry Letters, 18(1), 1-15. doi: 10.21608/blj.2022.229065
MLA
A.T. Keshta; Mohamed Moustafa; Hanaa Ashour; Faten Zahran. "Anti Cancer effect of two new synthized hetero cyclic compounds.", Biochemistry Letters, 18, 1, 2022, 1-15. doi: 10.21608/blj.2022.229065
HARVARD
Keshta, A., Moustafa, M., Ashour, H., Zahran, F. (2022). 'Anti Cancer effect of two new synthized hetero cyclic compounds.', Biochemistry Letters, 18(1), pp. 1-15. doi: 10.21608/blj.2022.229065
VANCOUVER
Keshta, A., Moustafa, M., Ashour, H., Zahran, F. Anti Cancer effect of two new synthized hetero cyclic compounds.. Biochemistry Letters, 2022; 18(1): 1-15. doi: 10.21608/blj.2022.229065
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