Metabolic syndrome: A Review Involving the Hedgehog Pathway, PGC-1α , and GLP Roles

Salah, Bassant; Abdelsalam, Hani; Khamis, Tarek; Diab, Abdelaziz; El-Dawy, Khalifa

doi:10.21608/blj.2023.314429

Metabolic syndrome: A Review Involving the Hedgehog Pathway, PGC-1α , and GLP Roles

Authors

¹ Physiology- Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt, 44511,

² Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt, 44511,

³ Laboratory of Biotechnology, Faculty of Veterinary Medicine, Zagazig University, Zagazig Egypt, 44519,

⁴ Biochemistry Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt, 44511,

10.21608/blj.2023.314429

Abstract

Metabolic syndrome (MetS) is a kind of metabolic disorder, including abdominal obesity, hyperglycemia, dyslipidemia, hypertension, etc. The prevalence of MetS is increasing substantially, making it a major public health issue in many nations. The morphogen Hedgehog (HH) signaling system plays a crucial role in controlling many aspects of embryonic development. The potential for pharmaceutical manipulation of the Hh pathway to improve outcomes in metabolic disorders has been demonstrated by researchers. The peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) has a strong correlation with the development of MetS and its principal sequelae, including obesity, cardiovascular illness, and hepatic steatosis. Glucagon-like protein 1 (GLP-1) is an antiobesogenic hormone that promotes glucose-induced beta-cell insulin secretion and suppresses alpha-cell glucagon synthesis. As these signaling and related regulatory modalities for regulating metabolism become more complex, this work aims to give a comprehensive understanding of the key signaling events involved. Furthermore, it explores the potential methods required to treat metabolic illnesses effectively.

Keywords