Biochemical studies on the protective effect of cobra venom against Melamine induced Nephrotoxicity in albino rats

Document Type : Original Article

Authors

1 Biochemistry Department, Faculty of Science, Zagazig University, Egypt

2 Chemistry department, faculty of Science, zagzig University, Egypt

3 Biochemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt

Abstract

Background: Melamine is a common pollutant that threatens human and animal health.The elevated concentrations of these compounds cause adverse effects in humans and animals. AIM: This paper aims to evaluate the protective effect of Egyptian cobra snake venom against melamine-induced Nephrotoxicity in rats. Methods: The current study was conducted on six groups of adult albino rats as follow. group I ( negative control):rats were I.P. injected with 2ml distilled water for all experiment period, group II( SV10µg/kg) :Rats were I.P. injected with 10 µg/kg snake venom, group III (SV20µg/kg):Rats were I.P. injected with 20 µg/kg Snake venom , group IV(melamine):Rats received 700mg/kg melamine ,group V(melamine+SV10µg/kg): Treated with 10 µg/kg snake venom, group VI( melamine+SV20µg/kg): Treated with 20 µg/kg snake venom. Results: Treatment with snake venom enhanced Nephrotoxicity induced by melamine by ameliorating kidney function and increasing apoptotic marker Caspase-3 ,and decrease level of cystatin C protein , also decrease inflammatory level marker IL-2, and expression level IL-10, INF-γ. Conclusion: Treatment with snake venom improved nephrotoxicity induced by melamine in albino rats.

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