Anti-rheumatic effect of phloretin in combination with Plaquenil against rheumatic impact of Complete Freund's adjuvant (CFA) in adult male rats

Document Type : Original Article

Authors

1 Department of Chemistry, Biochemistry Division, Faculty of Science, Fayoum University, Fayoum, Egypt

2 Zoology Department, Faculty of Science, Fayoum University, Fayoum, Egypt

Abstract

Objectives: For this investigation, the anti-rheumatic impacts of phloretin (ph) were examined both individually and in combination with Plaquenil (plq) against CFA-created arthritis in rats. Methods: 48 male rats were separated haphazardly into group (I): control; group (II): Plq; group (III): Ph; group (IV): CFA; group (V): Plq treated (Plq Tr); group (VI): Ph Tr; group (VII): Plq&Ph Tr; group (VIII): Ph protective (Ph Pr). Results: There was a notable increase in RF, Anti-CCP, TNF-α, IL-6, MDA, GPT, GOT, Urea, and Creat levels, and a marked drop in TAC levels and X-ray showed marked narrowing of joint space and diffuse swelling of the surrounding soft tissue and histopathological examination showed changes in articular cartilage and destruction of the adjacent bone in the CFA group compared to the control. In contrast, administration of Ph alone or combined with Plq results in an improvement of all biochemical parameters in the treated and protective groups, and X-ray, besides histopathological examination. Conclusion: Ph either alone or in combination with Plq, exhibited significant anti-arthritic activity in a CFA-induced rheumatoid arthritis model.

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