Ameliorative Effect Of Flaxseed On Ehrlich Carcinoma-Bearing Mice

Document Type : Original Article

Authors

1 Chemistry Department, Biochemistry division, Faculty of Science, Fayoum University, Fayoum, Egypt

2 Zoology Department, Faculty of Science, Fayoum University, Fayoum, Egypt

3 Pharmacognosy Department, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt

Abstract

Objectives: Owing to the deleterious effects of treatment modalities currently in use for cancer treatment the need to develop safe cancer treatments with minimum or no side effects became a critical need to save lives of patients. This study was conducted to assess the efficiency of using Flaxseed as an anti-tumor agent on mice-bearing Ehrlich Carcinoma (EC).
Methods: Twenty four male swiss albino mice were divided into four groups: group1 was control normal group; group2 served as an untreated tumor control group; group3 was a tumor-bearing mice group treated with Flaxseed and group4 was Flaxseed protected tumor-bearing mice group that was administered with Flaxseed for 15 days before tumor inoculation. Flaxseed treatment started at day "0" of tumor inoculation and was continued for 30 days followed by evaluation of anti-tumor effects, liver and kidney function tests, total antioxidant capacity, oxidative stress and anti-inflammatory markers.
Results: Flaxseed showed potent anti-tumor effects by reducing tumor volume and weight significantly with tumor control group with ameliorative effects on liver and kidney function tests that were significantly elevated in tumor control group. Tumor lowering effect on Total antioxidant capacity (TAC) and elevation of oxidative stress markers were potently ameliorated by Flaxseed, restoring their values to ones close to normal control. Tumor-induced elevation of the inflammatory marker C-reactive protein (CRP) was also reduced by Flaxseed administration returning to levels near normal control.
Conclusion: Flaxseeds exhibited potent protective and therapeutic anti-tumor, antioxidant and anti-inflammatory properties with ameliorative effect on tumor-induced adverse effects on liver and kidney.

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