The purpose of this study was to investigate the possible mechanisms of Crocus sativus saffron against diethylnitrosamine (DEN)-induced liver cancer in rats. Administration of Crocus sativus saffron at a dose of 300 mg/kg/day was started 2 weeks prior to the DEN and CCL4 injection and was continued for 42 days. Crocus sativus saffron significantly reduced the DEN-induced increase in the number and the incidence of hepatic dyschromatic nodules, saffron restored the superoxide dismutase, catalase and malondialdehyde levels and increased the expression of active caspase 3 and inhibited the formation of MMP9
Fikry, R., Zein, N., & Faozan, A. (2018). Properties of Crocus sativus Saffron on DEN-induced Hepatocellular Carcinoma in Rats. Biochemistry Letters, 14(1), 171-179. doi: 10.21608/blj.2018.47618
MLA
Reda Fikry; Nabila Zein; Asmaa Faozan. "Properties of Crocus sativus Saffron on DEN-induced Hepatocellular Carcinoma in Rats". Biochemistry Letters, 14, 1, 2018, 171-179. doi: 10.21608/blj.2018.47618
HARVARD
Fikry, R., Zein, N., Faozan, A. (2018). 'Properties of Crocus sativus Saffron on DEN-induced Hepatocellular Carcinoma in Rats', Biochemistry Letters, 14(1), pp. 171-179. doi: 10.21608/blj.2018.47618
VANCOUVER
Fikry, R., Zein, N., Faozan, A. Properties of Crocus sativus Saffron on DEN-induced Hepatocellular Carcinoma in Rats. Biochemistry Letters, 2018; 14(1): 171-179. doi: 10.21608/blj.2018.47618
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