Liver biopsy is invasive and prone to complications but it stills the gold standard for assessing hepatitis C virus (HCV)-related fibrosis. This study was designed to study non-invasive methods for the assessment of liver fibrosis. Our aim was to validate and compare the performance of MMP-8, upA in addition to GAL-3 as simple blood markers for different stages of liver fibrosis in HCV patients. The study was carried out on 90 individuals divided into the following groups: group 1: normal control, group 2: F1 = portal fibrosis without septa, group 3: F2 = few septa, group 4: F3 = numerous septa without cirrhosis and group 5: F4 = cirrhosis. Our results showed a positive correlation between MMP-8, upA and GAL-3 level and degree of liver fibrosis. We can conclude that, using of MMP-8, upA in addition to GAL-3 as simple biochemical markers for the assessment of hepatic fibrosis as alternative to liver biopsy.
Mohamed, F. Z., El-Deen, I. E. M., & Ismail, D. M. M. (2018). Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients. Biochemistry Letters, 14(1), 180-186. doi: 10.21608/blj.2018.47619
MLA
Faten Zahran Mohamed; Ibrahim El-Sayed M. El-Deen; Dina Mohamed Mohamed Ismail. "Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients", Biochemistry Letters, 14, 1, 2018, 180-186. doi: 10.21608/blj.2018.47619
HARVARD
Mohamed, F. Z., El-Deen, I. E. M., Ismail, D. M. M. (2018). 'Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients', Biochemistry Letters, 14(1), pp. 180-186. doi: 10.21608/blj.2018.47619
VANCOUVER
Mohamed, F. Z., El-Deen, I. E. M., Ismail, D. M. M. Combination of Fibrotic Markers accurately predict liver fibrosis in Hepatitis C Patients. Biochemistry Letters, 2018; 14(1): 180-186. doi: 10.21608/blj.2018.47619
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