Document Type : Original Article
Authors
1
Chemistry Department, Faculty of Science, El Fayoum University, El- Fayoum, Egypt
2
Pharmacology Department, Faculty of medicine, El Fayoum University, El- Fayoum, Egypt
3
Zoology Department, Faculty of Science, El Fayoum University, El- Fayoum, Egypt.
Abstract
Background: NAFLD is the most common liver disease all over the world. NASH can develop cirrhosis and hepatocellular carcinoma. Aim: Our research pointed to study the preventive effects of canagliflozin (CANA) or atorvastatin (ATO) on dexamethasone induced dyslipidemia and hepatic steatosis. Subjects and methods: Animals were grouped as control group; DEX group; ATO/DEX treated group; CANA/DEX treated group and ATO+CANA/DEX treated group. Results: Significant elevations in GSH, SOD and CAT activities, while high significant decreases in serum GOT, GPT, ALP, urea, blood glucose, CK-MB, LDH, T.G, T.C, MDA and P.C levels were demonstrated in treated groups as compared to DEX group in the experimental periods. Also, significant reductions in SGPT, SGPT, ALP, CK-MB, LDH, T.C and T.G levels were detected in CANA/DEX group as compared to ATO/DEX group. All these results were confirmed with histopathological findings where the severe damages and fatty degeneration in both kidney and liver tissues developed by dexamethasone administration resolved by administration of atorvastatin alone or better with Canagliflozin. Conclusion: These results indicate that antioxidant and hypolipidemic effects of canagliflozin may be responsible for the beneficial effects. Also, Canagliflozin was as effective as atorvastatin or combination of both in reducing dyslipidemia and hepatic steatosis.
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