Anti-tumor activity of some pyrazoline derivatives

Document Type : Original Article

Authors

1 Professor of Biochemistry, Faculty of Science, Zagazig University, Egypt.

2 Professor of Biochemistry, Faculty of Science, Mansoura University, Egypt.

Abstract

Background: Pyrazolines are heterorcycles that attracted considerable attention in the design of biologically active molecules , possess abroad spectrum of biological effective - ness including anticancer activities act as alkaylating agents in the chemotherapy of cancer., Changes instructureof pyrazoline derivatives offered a high degree of diversity as they are useful for the development of new therapeutic agents improved in potency and lesser toxicity, Aim: The main objective of the present study is to evaluate the chemotherapeutic effects of some novel substituted pyrazoline compounds against animal carcinogesis. Materials & Methods: The synthesized pyrazoline deriva-tives were characterized by IR spectroscopy, and then their effects on Ehrlich Carcinoma were studied by evaluation their antitumor activity (viability of tumor cells, and life span prolongation), and estimation of (Malondialdehyde ,Nitric oxide, Total antioxidant capacity levels and activities of Superoxide Dismutase , and Arginase) Results: Pyrazoline derivatives showed a significant reduction in the volume and count of Ehrlich cells. Also,they suggested potential antioxidant activity by elevation superoxide dismutase, Total Antioxidant capacity, and reduction of Malondialdehyde, Nitric oxide, and Arginase. Conclusion: The activities of synthesized pyrazoline compounds have potent antitumor, antioxidant, and decrease the survival of cancer cells. 

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