Gene polymorphism and some inflammatory biomarkers associated with coronary artery disease in Egyptian Population

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Science, Zagazig University

2 Department of Biochemistry, Faculty of Medicine, Zagazig University

Abstract

The main objective of our study was to evaluate the correlation between CRP and homocysteine and the susceptibility to coronary artery disease , Our study also aimed to declar the association between fibrinogen gene 455G/A, Methylene tetra hydrofolate reductase (MTHFR) C677T and C-reactive protein(CRP) +1059G>C gene polymorphisms and susceptibility to coronary artery disease in the Egyptian population. Our study involved two groups:50 healthy control (age 38 – 62 years, Gp 1), and 50 patients (age 40 - 62, Gp 2) with coronary artery disease. Homocysteine, hs-CRP were detected, fibrinogen 455G/A, MTHFR C677T and CRP+1059G>C polymorphisms were detected based on the Polymerase chain reaction and restriction enzyme fragment length polymorphism (PCR-RFLP) method. Our study showed that homocysteine and C-reactive protein were associated with the incidence of coronary artery disease. Our study also found a significant increase in the fibrinogen 455G/A (AA genotype) and the MTHFR C677T gene (TT genotype) in patients compared to the control group. However, there was no significant difference in patients and control group in the + 1059 G>C polymorphism (CC genotype). We thus concluded that the 455G/A and MTHFR C677T polymorphisms were associated with coronary artery disease rather than +1059G>C that seem to be not associated with coronary artery disease. 

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