Aqueous extract of Costus Specious ameliorates the toxic effect of lead acetate on transcriptional factors of erythropioesis

Shehata, Yousef M.; Dowidar, Mohamed F.; Ali, Haytham A.; Abdelazim, Aaser M.; Elmogy, Eman M.

doi:10.21608/blj.2014.63859

Aqueous extract of Costus Specious ameliorates the toxic effect of lead acetate on transcriptional factors of erythropioesis

Authors

¹ Professors of Biochemistry, Biochemistry Department, Faculty of Veterinary medicine, Zagazig University,44511, Zagazig, Egypt

² Lecturers of Biochemistry, Biochemistry Department, Faculty of Veterinary medicine, Zagazig University, 44511, Zagazig, Egypt

³ 3 Master of Biochemistry, Biochemistry Department, Faculty of Veterinary medicine, Zagazig University, 44511, Zagazig, Egypt

10.21608/blj.2014.63859

Abstract

Background: The increase use of medicinal plants during last 5 years encourages us to study the possible effects of Coustus Speciosus.
Objective: In the present study, we tested the effect of Costus speciosus on the toxicity of Lead acetate.
Results: The results showed an increase of EPO and high expression levels of GATA-1 and FOG-1 while there is a low expressional level of SCF in animals treated with Costus speciosus.
Conclusion: Costus Specious has the ability to ameliorate the toxicity of lead acetate on erythropioesis.

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