EFFECT OF CORIADRUM SATIVUM ON EXPERIMENTALLY IDUCED HEPATOTOXICITY OF CARBON TETRACHLORIDE IN RATS

Zein, Nabila; Abd Elghani, Essam; Talat, Eman

doi:10.21608/blj.2014.63860

EFFECT OF CORIADRUM SATIVUM ON EXPERIMENTALLY IDUCED HEPATOTOXICITY OF CARBON TETRACHLORIDE IN RATS

Authors

¹ Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig University

² 2Chemistry Department, Faculty of Science, Zagazig University

³ 1Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig University

10.21608/blj.2014.63860

Abstract

Objective: The aim of this study was to investigate the possible anti-fibrotic effect and antioxidant role of Coriandrum sativum (CS) extract against Carbon tetrachloride (CCL4)induced liver fibrosis in adult male rats. Method: The extracted CS was proved by phytochemical analysis (thin layer chromatography (TLC)). This study was carraidout on (72) rats these animals were divided into six groups of (72) rats The first group is negative control group. The second group is Positive control group .The third group is Preventive group. The forth group is Therapeutic group. The fifth group is Silymarine group. The sixth group is Combination group.Result: The TLC analysis revealed the presence of some important polyphenolic compounds as Kaempferol ,Quercetin , 3 , -OMe quercetin , 4 ,OMe quercetin , Acacetin and some of phenolic acids e.g Vanillic acid , p – Coumaric acid , Cis – Ferulic acid , Trans – Ferulic acid which could be responsible for the anti-oxidant activity .
Treatment with CS significantly decreased the elevated plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) while increased the albumin level. It also inhibited the formation of lipid peroxidative products Malondialdehyde (MDA) and nitric oxide (NO) during CCl4 administration. Moreover, treatment CS extract brought significant restoration of the haematological parameters to values that were comparable to those of the control. CS, treatment enhances the liver and kidney health (which confirmed by histopathological studies). Conclusion: The present study indicates that the coriandrum sativum extract possess significant anti-fibrotic and antioxidant activity in liver against experimental hepatotoxicity and nephrotoxicity in vivo. Increasing CS consumption is recommended, especially in cases of heavy contaminants and hepatic and renal disorder.

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