MODULATION OF INTERLEUKIN-6 AND IMMUNOGLOBULINS IgG AND IgM LEVELS AFTER MULTIPLE ORAL EXPOSURE TO LAMBDA-CYHALOTHRIN IN RATS

Authors

1 Zoology Department , Faculty of Sciences , Zagazig University

2 Department of Clinical Pathology , Faculty of Medicine , , Zagazig University

Abstract

 




 Lambda-Cyhalothrin (LCT) is a synthetic pyrethroid insecticide used worldwide in agriculture , home best , and disease vectors control . The objective of this study was to investigate the propensity of LCT to induce changes in some humoral immune parameters in adult male Sprague Dawley rats . Animals were divided into four groups (5 rats each) . The 1st and 3rd groups were orally given 1/10LD50 (12.76 mg/kg body wt.) every other day for 8 weeks. The 2nd and 4th groups were orally given dist. water every other day for 8 weeks and served as controls for the 1st and 3rd groups respectively . Blood samples were collected from each animal under ether anesthesia through heart puncture and sera were separated , at the 1st and the 15th days post LCT administration form groups 1 and 2 and groups 3 and 4 respectively . Data obtained revealed that oral LCT induced a significant decrease in IL-6, and significant increases in serum IgG and IgM concentrations. Significant increases in serum AST activity , total protein and albumin concentrations and non-significant decrease in serum ALT activity . Recovery from these changes were dependent on the measured parameter. 

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