ESTIMATION OF SOME CARCINOGENIC PESTICIDES OVERLOAD IN HUMAN ADIPOSE TISSUE

Polychlorinated biphenyls (PCBs) are potentially
hazardous compounds in the environmental pollution for
human beings persistent. The high lipophilicity and the
resistance to biodegradation of PCBs allow the
bioaccumulation of these chemicals in the fatty tissues of
organisms.To test the hypothesis that the amount and
quality of organochlorine residues in adipose tissue
related to the tumor incidence, the PCBs body burden in
patients was studied. The objective of this study was to
determine the levels of PCBs in the adipose tissue of
different patients lived in Delta Egypt especially Al-
Dakhelia, Al-Garbia, and Damietta which were the most
probably used pesticides. For this purpose, levels of eight
major persistent PCB congeners (IUPAC Numbers: 101,
118, 138, 153,170, 180, 183, 187) and the DDT metabolite
p, p' DDE, p, p' DDD and p, p' DDT ,HCH were
measured in 25 patients adipose tissue samples by gas
chromatography with electron capture detection (GCECD).
The concentrations of PCB 28, PCB 52 and PCB
101 were found to be higher than those found in
industrialized countries.
Also breast cancer women showed higher median
Hussien, M. EL-Shafei
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values of (138, 153 and 180) with respect to brain, lung,
liver, and prostate cancer men. A positive correlation (P
<0.05) was found between the age of donors and the
tissue levels of PCBs 28,118,138, 153,170,180,183,187
and 188, and also their is a positive correlation of both p,
p' DDT and DDE with age in females.
The results are compared with the similar studies from
other countries, the higher level of these compounds
detected in this study seems to be similar to results
obtained in other countries.