THERAPEUTIC EFFECTS OF CURCUMIN ALONE AND IN COMBINATION WITH DOXORUBICIN AGAINST IN VIVO INDUCED BREAST CANCER

Document Type : Original Article

Authors

1 Biochemistry Division, Dept. of Chemistry, Faculty of Science, Zagazig University

2 Faculty of Science, Biochemistry Division , Alexandrina University

Abstract

Drug resistance during tumor progression is a true problem as this is
the major reason for the failure of breast cancer therapy. High constitutive
activation of nuclear factor kappa B ( NF-kB) has been found in different
cancers, creating an environment conducive for chemotherapeutic
resistance. Curcumin, one of the most studied chemo preventive agents, is
a natural compound extracted from Curcuma longa L. that allows
suppression, retardation or inversion of carcinogenesis. Doxorubicin
(DOX) is a drug that is widely used for the treatment of a variety of
cancers including breast and liver cancers. This study aims to investigate
the effect of combination of curcumin with doxorubicin in breast cancer
treatment and provide a new suitable method to overcome cancer
resistance. Results: We found that administration of curcumin (200mg/kg
b.w.) with doxorubicin (1.25 mg/kg b.w.) results in disappearance of tumor
cells (EAC) and results in highly significance decrease of NF-kB. An antioxidant
effect of curcumin in vivo was observed; our results investigate a
significant increase in antioxidant enzymes.. Conclusion: Curcumin has a
strong inhibitory activity against tumors. The combination of curcumin
with doxorubicin resulted in a synergistic antitumor activity. These results
suggest that curcumin can be developed into an adjuvant
chemotherapeutic drug to overcome drug resistance of cancer.

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