ANGIOTENSIN CONVERTING ENZYME GENOTYPE PREVALENCE AMONG EGYPTIAN PRIMARY NEPHROTIC AND END STAGE RENAL DISEASES PATIENTS

Authors

1 Biochemistry Division, Dept. of Chemistry, Faculty of Science, Zagazig University

2 Urology & Nephrology center, Mansoura University, Egypt

Abstract

The Renin-Angiotensin system (RAS) is a key regulator of both
blood pressure and kidney functions and their interaction. In such a
situation, genetic variability in the genes of different components of
RAS is likely to contribute for its heterogeneous association in the
renal disease patients. Angiotensin converting enzyme-1 (ACE-1) is
an important component of RAS which determines the vasoactive
peptide Angiotensin-II. In the present study, we have investigated
103 end stage renal diseases (ESRD), 104 primary nephrotic (P.N)
patients and 102 normal healthy controls from Mansoura city in
Egypt to deduce the association between ACE gene polymorphism
and ESRD, P.N. The selected samples were assayed for genotyping
of ACE I/D by (PCR) based DNA amplification using specific
flanking primers. The results revealed that there was a significance
distribution in DD genotype between ESRD and control group
(p<0.05), with risk value (OR>1) which resulting in increasing the
risk for ESRD. There was significance distribution in ID genotype
between ESRD and control group (p<0.05), without disease risk (OR
<1). Based on these observations we conclude that ACE DD 

genotype implicate a strong possible role in the in renal damage
among Egyptians. The study will help in predetermining the timing,
type and doses of therapy for ESRD patients.
 

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